Abstract. Geosystemics (De Santis 2009, 2014) studies the Earth system as a whole focusing on the possible coupling among the Earth layers (the so called geo-layers), and using universal tools to integrate different methods that can be applied to multi-parameter data, often taken on different platforms. Its main objective is to understand the particular phenomenon of interest from a holistic point of view. In this paper we will deal with earthquakes, considered as a long term chain of processes involving, not only the interaction between different components of the Earth’s interior, but also the coupling of the solid earth with the above neutral and ionized atmosphere, and finally culminating with the main rupture along the fault of concern (De Santis et al., 2015a). Some case studies (particular emphasis is given to recent central Italy earthquakes) will be discussed in the frame of the geosystemic approach for better understanding the physics of the underlying complex dynamical system.